LYOMAC Complete Commercial Lyophilization Solutions
(200~1,000 Liters capacity )
✔ Higher production capacity to expand your output ✔ ✔ ✔ Superior thermal efficiency & stable batch performance
✔ Fully cGMP, FDA & 21CFR compliant design
Lyomac offers highly customizable freeze-drying solutions tailored to your specific product types, production capacities（range from 4-1,000 Liters）, and customerize design for your facility layouts. Whether you need special performance for your process, GMP-compliant systems for vials or API materials, our diverse range of process options and specialized configurations ensures optimal performance. For more details on capacity scaling and customized solutions, please review the information below.
Expert on commercial production for API and vial lyophilization
As a professional manufacturer of commercial freeze dryers, we have successfully delivered over 300 projects globally in the past two decades. These installations, primarily dedicated to the production of APIs, sterile raw materials, and injectable vials, fully comply with FDA and cGMP standards.
We offer extensive customization options, backed by comprehensive local support and long-term maintenance services. Contact us today to select the ideal equipment for your needs, including our range of advanced electronic solutions.
Models and specifications for your needs:
The industrial model freeze dryer with drying capacity up to 1,000Liters,cover most demand for vial or other material commercial production,compliance with cGMP and FDA. More optional systems available, main features are:
◆Automatic shelf stoppering under vacuum
◆Automatic control for freeze drying,SIP,CIP and De-icing system
◆Auto dosing system for API liquid / Auto loading for vials
◆Scada control system comliance with GAMP regulation and save up to thousand recipes
◆Shelf flatness less than 1.0mm,temperature uniformity less than 1C.
◆Energy saving control system by control compressor and vacuum pump
◆Oil or dry vacuum pump
◆Flexible arrangement design,suit user’s plant layout,thus space saved
LYOMAC production-grade freeze dryer systems are built for continuous, scalable sterile manufacturing for pharmaceutical factories, CDMO and large-scale food processing facilities.
Equipped with proprietary radiant shelf heating and innovative trayless tilting shelf design. Material can be directly placed on shelves without separate trays. After drying, shelves tilt automatically for simple bulk discharging, drastically reducing tray cleaning, sterilization labor and contamination risks.
Systems support integration with automatic vial loading/unloading frames, filling lines and aseptic isolators for fully closed production workflows, fully compliant with cGMP, FDA and Annex 1 standards.
Standard Specifications
- Shelf Area Range: 10 ~ 50 ㎡
- Shelf Temperature Range: -55 ℃ ~ +80 ℃
- Shelf Temperature Uniformity: ≤ ±1.0 ℃
- Condenser Temperature: ≤ -75 ℃
- Ultimate Vacuum: ≤ 1 Pa
- Heating Method: Conductive shelf heating
- Core Feature: Trayless tilting shelf for automatic discharge
- Wetted Components: 316L stainless steel, polished surface
- Control: Full SCADA platform, 21 CFR Part 11 compliance, redundant key components
Standard Built-in Functions
Energy-saving inverter control, automatic fault alarm with email notification, maintenance pre-warning, real-time data monitoring.
Optional Configuration
Full CIP & SIP system, automatic vial loading & unloading system, vacuum stoppering, low oxygen anti-oxidation enclosure, eutectic point online detection, remote monitoring module.
Typical Applications
> Commercial peptide production, sterile injectable API, biotherapeutics, large-scale probiotic manufacturing, food & nutritional raw material mass production.
> Regenerative & Aesthetic Peptide Lyophilization
> 503A / 503B Compounding Pharmacy Solutions
Model List：
| Parameter | LYOPRO-25.0 | LYOPRO-30.0 | LYOPRO-40.0 | LYOPRO-50.0 |
|---|---|---|---|---|
| Drying Capacity (Liter) | 500 | 600 | 800 | 1000 |
| Shelf Size (mm) | 1500×1500 | 2000×1500 | 2000×1500 | 2200×1500 |
| Useful Shelf No | 11 | 10 | 14 | 15 |
| Vial Loading Quantity φ16 | 100000 | 120000 | 175000 | 200000 |
| Vial Loading Quantity φ22 | 50000 | 60000 | 85000 | 100000 |
| Inter-Shelf Distance (mm) | 100 | 100 | 100 | 100 |
| Shelf Ultimate Cooling Temp (°C) | -55 | -55 | -55 | -55 |
| Condenser Ultimate Cooling Temp (°C) | -75 | -75 | -75 | -75 |
| Ultimate Vacuum (Pa) | ≤1 | ≤1 | ≤1 | ≤1 |
| Installation Dimension (mm) | 7200×3000×4200 | 7600×3000×4200 | 7600×3200×4500 | 7500×2300×4700 |
| Weight (Kgs) | 20000 | 25000 | 30000 | 35000 |
| Power (KW) | 135.0 | 147.0 | 179.0 | 215.0 |
| Parameter | LYOPRO-10.0 | LYOPRO-13.0 | LYOPRO-16.0 | LYOPRO-20.0 |
|---|---|---|---|---|
| Drying Capacity (Liter) | 200 | 260 | 320 | 400 |
| Shelf Size (mm) | 1200×900 | 1200×1200 | 1200×1200 | 1500×1200 |
| Useful Shelf No | 9 | 9 | 11 | 11 |
| Vial Loading Quantity φ16 | 40000 | 56000 | 68000 | 80000 |
| Vial Loading Quantity φ22 | 20000 | 28000 | 34000 | 40000 |
| Inter-Shelf Distance (mm) | 100 | 100 | 100 | 100 |
| Shelf Ultimate Cooling Temp (°C) | -55 | -55 | -55 | -55 |
| Condenser Ultimate Cooling Temp (°C) | -75 | -75 | -75 | -75 |
| Ultimate Vacuum (Pa) | ≤1 | ≤1 | ≤1 | ≤1 |
| Installation Dimension (mm) | 6000×1750×3800 | 6800×2000×3800 | 6800×2000×4200 | 7500×2000×4200 |
| Weight (Kgs) | 10000 | 12500 | 15000 | 17500/td> |
| Power (KW) | 63 | 77.5 | 91.5 | 120 |
