Lyomac offer Flexible
Lab lyophilizer , support your R&D
(2~12 Liters capacity )
✓ More flxible for your requirement vial, flask and tray load
✓ Better efficiency and performance
✓ Easy to start and run
✓Maintenance free for user
Engineered for Flexibility and Insight on product lyophilization process
LLYOMAC lab-scale lyophilizers are not merely scaled-down versions of production freeze dryers. Designed as compact, high-precision research platforms, they deliver outstanding thermal stability and comprehensive data acquisition for formulation screening, cycle development and lyophilization process optimization.
All process parameters are continuously recorded and accessible via the HMI and SCADA system, enabling consistent, traceable data comparison throughout your R&D work.
1. Robust Process Monitoring & Analytical Capability
Built to support Quality by Design (QbD) principles, our lab units integrate standard high-performance sensor systems for reliable lyophilization characterization:
- Precise shelf temperature control with excellent uniformity, minimizing batch-to-batch deviation for thermally sensitive peptides, injectables and biopharmaceuticals.
- Dual vacuum measurement system utilizing Pirani and capacitance manometers. Accurately identify primary drying endpoints and maintain stable vacuum conditions across the full lyophilization cycle.
- Optional wireless temperature probes, TDLAS and mass spectrometry modules available for customers requiring advanced in-depth process research.
2. Seamless, Risk-Minimized Scale-Up
The chamber geometry, thermal fluid circuit and control software of our 2–12 L laboratory models share identical design logic with LYOMAC industrial production freeze dryers.
Lyophilization cycles developed and optimized on lab-scale equipment can be directly transferred to pilot and commercial production systems. This eliminates repetitive process rework, cuts development costs and shortens your path to market.
3. Compact Footprint & Long-Term Operational Stability
Space-saving compact layout fits neatly inside laboratory environments. Optimized mechanical systems ensure long-run stability, lower maintenance frequency and consistent performance over years of continuous R&D operation.
Lyomac offer below option systems:
✔CIP and SIP system
✔Stoppering system for vial rubber cap cloure
✔Isolate flange design for attach to sterile isolator system
✔Eutectic devices for developer to analysis the proper tempreature to support obtain best process
Versatile Applications: From Concept to Clinic
LYOMAC laboratory lyophilizers are designed for R&D, formulation screening, small-batch trials for peptides, biologic samples, diagnostic reagents and nutraceutical raw materials. Built with radiant shelf heating technology, units deliver uniform temperature distribution to protect active ingredients. Smooth scale-up path to pilot and production systems ensures consistent lyophilization cycle transfer.
Standard Specifications
- Shelf Area Range: 0.2 ~ 0.6 ㎡
- Shelf Temperature Range: -60 ℃ ~ +70 ℃
- Shelf Temperature Uniformity: ≤ ±1.0 ℃
- Condenser Temperature: ≤ -80 ℃
- Ultimate Vacuum: ≤ 2Pa
- Heating Method: Conductive shelf heating
- Wetted Material: 316L stainless steel
- Control System: PLC + Touchscreen, recipe storage, data recording
- Operation Mode: In-situ freeze drying
Optional Configuration
- Auto hydraulic vial stoppering system
- CIP SIP for sterile product
- Flask manifold for bulk lab samples
- 21 CFR Part 11 compliant SCADA software
- Isolator connection design with sliding door
Typical Applications
Peptide research, compounding pharmacy small trials, probiotic strain testing, diagnostic reagent development, university & CRO laboratory work.
Whether you are stabilizing a novel protein, developing a complex liposome formulation, or producing clinical trial material, Lyomac offers a versatile solution:
- Process Development: Rapidly screen formulations and optimize freeze-drying cycles (annealing, sublimation rates) with precise control over shelf temperature ($\pm 1^\circ$C) and vacuum levels.
- Sample Preparation: Ideal for preparing high-quality samples for stability testing and analytical characterization.
- Clinical Trial Batches: The robust design allows for the production of sterile, small-batch clinical supplies.
- High-Value Small Batch Production: Perfect for extremely high-value APIs or personalized medicines where large-scale equipment is inefficient.
- Regenerative & Aesthetic Peptide Lyophilization
- 503A / 503B Compounding Pharmacy Solutions
- Lab & Pilot Scale R&D Systems
Advanced Aseptic Capability
Understanding the increasing need for sterility even at the R&D stage, Lyomac offers integrated containment solutions.
- Isolator Integration: Our 2-12L units can be fully integrated with Isolators or RABS (Restricted Access Barrier Systems). This allows for the safe handling of potent compounds (HPAPIs) and ensures aseptic conditions for sterile injectable development, mirroring commercial aseptic processing lines.
Why Leading Labs Choose Lyomac
With decades of experience delivering FDA and cGMP-compliant solutions, Lyomac combines robust engineering with cutting-edge software. Our local service teams and comprehensive maintenance support ensure your research never stops.
Accelerate your drug development journey with Lyomac. Contact us today to configure the ideal freeze-drying solution for your laboratory.
Lyomac developed lab freeze dryer biotech,pharmaceutical ,vaccine and other industry freeze drying process. it is widely used process development, Research and development.
◆Less Utility,Just need electrical plug in to operate.
◆Build with computer SCADA system,precise data report will be record
◆Low noise running, good for office enviroment.
◆Optional to build with stainless steel panel,sterile room allowed to install in sterile room.
◆Optional to be with stoppering,eutectic detector,CIP and SIP
LYOPRO Series Lab & Pilot Lyophilizer Specification:
| Parameter | LYOPRO-0.2 | LYOPRO-0.4 | LYOPRO-0.6 |
|---|---|---|---|
| Model | LYOPRO-0.2 | LYOPRO-0.4 | LYOPRO-0.6 |
| Drying Capacity (Liter) | 4 | 8 | 12 |
| Shelf Size (mm) | 400×300×13 | 400×300×13 | 500×300×13 |
| Useful Shelf Number | 2 | 3 | 4 |
| Vial Loading Quantity Φ12 | 500 | 875 | 1300 |
| Inter-Shelf Distance (mm) | 75 | 75 | 75 |
| Condenser Ultimate Cooling Temperature (°C) | -40 | -50 | -70 |
| Ultimate Vacuum (Pa) | ≤3 | ≤3 | ≤3 |
| Installation Dimension (mm) | 1400×900×1800 | 1400×900×1900 | 1500×1200×1900 |
| Weight (Kgs) | 300 | 500 | 800 |
| Power (KW) | 4.0 | 5.0 | 8.0 |
